HCID 90030495, compound → HCID 72944422, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenoxy)piperidine-1-carboxylate (80 mg, 0.134 mmol) was deprotected in HCl in methanol (5 ml). This afforded 33 mg (40.2% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.75-8.60 (bs, 1H), 8.37 (s, 1H), 7.66 (s, 1H), 7.48-7.44 (t, 1H), 7.42-7.37 (q, 1H), 7.33-7.29 (m, 2H), 7.11-7.04 (m, 3H), 6.93-6.91 (d, 1H), 5.41 (s, 2H), 4.85-4.82 (m, 1H), 3.48-3.41 (m, 2H), 3.28-3.23 (m, 2H), 2.25-2.28 (m, 8H), 2.12-2.06 (m, 2H). MS: m/z=496.3 (M+1), HPLC: 96.84% in method A.

Provenance & Evidence