HCID 118523943, compound → HCID 90030600, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(3-(3-(1-phenethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)piperidine-1-carboxylate (60 mg, 0.106 mmol) was deprotected in HCl in methanol (5 ml). This afforded 20 mg (32.4% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.65-8.60 (bs, 1H), 8.52 (s, 1H), 7.92 (s, 1H), 7.87 (s, 1H), 7.74 (s, 1H), 7.61-7.58 (d, 2H), 7.53-7.41 (t, 1H), 7.33-7.26 (d, 1H), 7.26-7.22 (t, 2H), 7.15-7.09 (m, 3H), 4.49-4.45 (t, 2H), 3.41-3.38 (d, 2H), 3.22-3.18 (t, 2H), 2.99-2.93 (t, 2H), 2.77-2.76 (d, 2H), 2.01-1.90 (m, 3H), 1.56-1.46 (m, 2H). MS: m/z=462.7 (M+1), HPLC: 88.14% in method A.

Provenance & Evidence