Diisopropylethylamine → HCID 118523956, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(6-(piperidin-4-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride (85 mg. 0.132 mmol) was alkylated using (S)-2-methyloxirane (16 mg, 0.264 mmol), DIPEA (68 mg, 0.528 mmol) and ethanol (5 mL) to get 86 mg (97.8% yield) of the titled compound. MS: m/z=665.2 (M+1).

Provenance & Evidence