Diisopropylethylamine → (S)-1-(4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)propan-2-ol

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridinehydrochloride (step 1 example 103) (50 mg. 0.077 mmol) was alkylated using (S)-2-methyloxirane (9 mg, 0.155 mmol), DIPEA (29 mg, 0.231 mmol) and ethanol (2 mL) to get 25 mg (9.8% yield) of the titled compound. MS: m/z=664.8 (M+1).

Provenance & Evidence