Lithium Hydroxide → HCID 90030331, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 5-(4-(4-methylpiperazin-1-yl)phenyl)-3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (60 mg, 0.097 mmol) was hydrolyzed by lithium hydroxide (12 mg, 0.291 mmol) in THF/methanol/water (1/1/1 ml) to afford 20 mg (45.0% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.24 (s, 1H), 7.88 (s, 1H), 7.78 (s, 1H), 7.67-7.65 (d, 2H), 7.61 (s, 1H), 7.28-7.15 (m, 6H), 4.49-4.45 (t, 2H), 4.00-3.97 (d, 2H), 3.69-3.66 (d, 2H), 3.23-3.12 (m, 6H), 3.02 (s, 3H). MS: m/z=462.9 (M+1), HPLC: 96.28% in method B.

Provenance & Evidence