Lithium Hydroxide → HCID 90030763, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 2-(4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(methylsulfonamido)phenyl)piperazin-1-yl)acetamide (80 mg, 0.1 mmol) was hydrolyzed with lithium hydroxide (13 mg, 0.3 mmol) in THF/methanol/Water (2/2/1 mL) to yield 15 mg (23.6% yield. 1H NMR (DMSO-d6, 400 MHz): δ 8.45-8.40 (m, 3H), 8.3 (s, 1H), 7.94 (s, 1H), 7.767-7.761 (d, 1H), 7.615-7.610 (d, 1H), 7.53-7.51 (d, 1H), 7.40-7.33 (m, 2H), 7.24-7.07 (m, 4H), 5.38 (s, 2H), 3.18 (s, 3H), 2.95-2.92 (m, 6H), 2.657 (s, 5H). MS: m/z=603.15 (M+1), HPLC: 93.36% in method A.

Provenance & Evidence