反应详情

Using similar reaction conditions as described in step-ii of example-1, 5-bromo-3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (compound of Step-i of example 9) (200 mg, 0.380 mmol) was coupled with tert-butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (175 mg, 0.418 mmol) using sodium carbonate (121 mg, 1.1422 mmol) and Pd(dppf)Cl2 (14 mg, 0.019 mmol) in toluene/ethanol/water (4/4/2 mL). This afforded 190 mg (68.0% yield) after purification by column (Silica gel 60/120) using 40% ethyl acetate in hexane as eluent. MS: m/z=737.1 (M+1).

1. customreaction conditions
2. customThis afforded 190 mg (68.0% yield) after purification by column (Silica gel 60/120)