Hydrochloride methanol → 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(3-methoxy-4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxyphenyl)piperazine-1-carboxylate (190 mg, 0.257 mmol) was deprotected in methanol/HCl in diethyl ether (5/3 ml) to afford 120 mg (69.0% yield) of the titled compound. MS: m/z=637.3 (M+1).

Provenance & Evidence