HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → HCID 90031113, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | HCID 90030526 | HCID 90030526 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90031113 | HCID 90031113 | 95.5% |
Reaction Steps
Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methylphenyl)piperazine-1-carboxylate (210 mg, 0.291 mmol) was deprotected in methanol/HCl in dioxane (5/10 ml) to afford 172 mg (95.5% yield) of the titled compound. MS: m/z=621.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-d5f7dd0a6ab545138c0c880e2215e595 |
| Source note | uspto-grants-2016_05 |