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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 531705Generated: October 31, 2026

Hydrochloride methanol → HCID 90031113, compound

https://huagongshe.com/reaction/531705

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloride methanolHCID 21893726—
ReactantHCID 90030526HCID 90030526—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 90031113HCID 9003111395.5%

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methylphenyl)piperazine-1-carboxylate (210 mg, 0.291 mmol) was deprotected in methanol/HCl in dioxane (5/10 ml) to afford 172 mg (95.5% yield) of the titled compound. MS: m/z=621.3 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09353107B2
Source datasetuspto-grants-2016_05
ORD IDord-d5f7dd0a6ab545138c0c880e2215e595
Source noteuspto-grants-2016_05