HCID 90034136, compound → HCID 118524009, compound

HRID 531726Notes

Reaction equation

HRID 531726 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:40]2[CH2:45][CH2:44][N:43](C(OC(C)(C)C)=O)[CH2:42][CH2:41]2)[CH:5]=[CH:6][C:7]=1[C:8]1[CH:9]=[C:10]2[C:16]([C:17]3[CH:18]=[N:19][N:20]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=4)[CH:21]=3)=[CH:15][N:14]([S:30]([C:33]3[CH:39]=[CH:38][C:36]([CH3:37])=[CH:35][CH:34]=3)(=[O:32])=[O:31])[C:11]2=[N:12][CH:13]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([N:40]2[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]2)[CH:5]=[CH:6][C:7]=1[C:8]1[CH:9]=[C:10]2[C:16]([C:17]3[CH:18]=[N:19][N:20]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=4)[CH:21]=3)=[CH:15][N:14]([S:30]([C:33]3[CH:34]=[CH:35][C:36]([CH3:37])=[CH:38][CH:39]=3)(=[O:32])=[O:31])[C:11]2=[N:12][CH:13]=1

Participants

3

Reactant 1

HCID 90034136HCID 90034136, compound

Product 1

HCID 118524009HCID 118524009, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(3-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (150 mg, 0.206 mmol) was deprotected in TFA/DCM (2/1 ml) to afford 120 mg (93% yield) of the titled compound. MS: m/z=625.1 (M+1).

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-547052bb881648b1bdf5eed7c99f93d4
Source dataset
uspto-grants-2016_05
Patent number
US09353107B2

Reaction notes

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