Lithium Hydroxide → HCID 90031772, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(3-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)propan-2-ol (100 mg, 0.146 mmol) was hydrolyzed with lithium hydroxide (30 mg, 0.73 mmol) in THF/methanol/water (3/2/1 mL) to yield 45 mg (58.4% yield) of desired product. 1H NMR (CD3OD, 300 MHz): δ 8.39-8.36 (m, 2H), 8.15 (s, 1H), 7.914-7.912 (d, 1H), 7.67 (s, 1H), 7.59-7.50 (t, 1H), 7.42-4.30 (m, 1H), 7.11-6.92 (m, 5H), 5.42 (s, 2H), 4.30-4.20 (m, 1H), 4.00-3.60 (m, 4H), 3.27-3.13 (m, 4H), 1.27-1.25 (d, 3H). MS: m/z=529.3 (M+1), HPLC: 95.98% in method A.

Provenance & Evidence