HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 90031406, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | HCID 86710980 | HCID 86710980 | — |
| Reactant | 5-bromo-3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 118200974 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| Product | HCID 90031406 | HCID 90031406 | — |
Reaction Steps
Using similar reaction conditions as described in step-ii of example-1, 5-bromo-3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (compound of Step-i of example 9) (150 mg, 0.28 mmol) was coupled with 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-ol (130 mg, 0.428 mmol) using sodium carbonate (89 mg, 0.84 mmol) and Pd(dppf)Cl2 (10 mg, 0.14 mmol) in DME/water (10/1 mL). This afforded 130 mg (crude). MS: m/z=622.5 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-b8ade7030a544810963925196a9bf6bb |
| Source note | uspto-grants-2016_05 |