Lithium Hydroxide → HCID 90030666, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 1-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidin-4-ol (130 mg, 0.209 mmol) was hydrolyzed with lithium hydroxide (28 mg, 0.62 mmol) in THF/methanol/water (3/3/1 mL) to yield 35 mg (28.7% yield) of desired product. 1H NMR (CD3OD, 300 MHz): δ 8.56 (s, 2H), 8.24 (s, 1H), 7.97-7.94 (m, 3H), 7.74-7.70 (m, 3H), 7.38-7.35 (m, 1H), 7.12-6.99 (m, 3H), 4.10-4.08 (m, 1H), 3.90-3.84 (m, 2H), 3.64-3.57 (m, 2H), 2.27-2.20 (m, 2H), 2.04-1.97 (m, 2H). MS: m/z=468.4 (M+1), HPLC: 91.74% in method B.

Provenance & Evidence