Hydrochloric Acid → 3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride

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Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (example 40 step 1) (232 mg, 0.315 mmol) was deprotected in methanol (5 ml), HCl in dioxane (5 ml). This afforded 198 mg (93.8% yield) of the titled compound. MS: m/z=651.1 (M+1).

Provenance & Evidence