(2S)-2-Methyloxirane → (S)-1-(4-(4-(3-(1-(3-fluorobenzyl)-5-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)propan-2-ol

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 3-(1-(3-fluorobenzyl)-5-methyl-1H-pyrazol-4-yl)-5-(4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride (230 mg, 0.349 mmol) was alkylated using (S)-2-methyloxirane (41 mg, 0.69 mmol) DIPEA (136 mg, 10 mmol) and ethanol (5 mL) to get 200 mg (crude) of the titled compound.

Provenance & Evidence