Trifluoroacetic acid methylene chloride → 3-(1-phenethyl-1H-pyrazol-4-yl)-5-(6-(piperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

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Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperazine-1-carboxylate (140 mg, 0.199 mmol) was deprotected with TFA/DCM (2/1 ml). This afforded 110 mg (91.6% yield) of the titled compound. MS: m/z=604.1 (M+1).

Provenance & Evidence