Lithium Hydroxide → 5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(1-phenethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (50 mg, 0.088 mmol) was hydrolyzed with lithium hydroxide (18 mg, 0.44 mmol) in THF/methanol/water (2/2/1 mL) to yield 40 mg (98.5% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.55-8.50 (d, 2H), 8.40 (s, 1H), 8.19-8.10 (dd, 1H), 7.89-7.84 (d, 2H), 7.68 (s, 1H), 7.24-7.21 (m, 3H), 7.15-7.11 (m, 3H), 4.50-4.50 (t, 2H), 3.20-3.10 (t, 2H), 2.98 (s, 3H). MS: m/z=464.2 (M+1), HPLC: 93.96% in method A.

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