Lithium Hydroxide → HCID 90064907, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-6-methoxypyridin-2-yl) piperazin-1-yl)propan-2-ol (60 mg, 0.086 mmol) was hydrolyzed with lithium hydroxide (36 mg, 0.862 mmol) in THF/methanol/water (10/5/2 mL) to yield 14 mg (25% yield) of desired product. 1H NMR (CD3OD, 400 MHz): δ 8.615-8.612 (d, 1H), 8.51 (s, 1H), 8.20 (s, 1H), 7.95 (s, 1H), 7.82-7.80 (d, 1H), 7.76 (s, 1H), 7.41-7.36 (m, 1H), 7.14-7.12 (d, 1H), 7.08-7.01 (m, 2H), 6.61-6.59 (d, 1H), 5.44 (s, 2H), 4.52 (s, 2H), 4.29-4.24 (m, 1H), 3.96 (s, 3H), 3.74 (s, 2H), 3.36 (s, 2H), 3.26-3.11 (m, 4H), 1.28-1.27 (d, 2H). MS: m/z=542.2 (M+1), HPLC: 96.86% in method B.

Provenance & Evidence