Diisopropylethylamine → (S)-1-(4-(5-(3-(1-(3-methylbenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperazin-1-yl) propan-2-ol

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 3-(1-(3-methylbenzyl)-1H-pyrazol-4-yl)-5-(6-(piperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride (120 mg. 0.187 mmol) was alkylated using (S)-2-methyloxirane (33 mg, 0.562 mmol), DIPEA (145 mg, 1.124 mmol) and ethanol (5 mL) to get 100 mg (crude) of the titled compound. MS: m/z=662.3 (M+1).

Provenance & Evidence