Lithium Hydroxide → 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (70 mg, 0.105 mmol) was hydrolyzed by lithium hydroxide (25 mg, 0.63 mmol), THF/methanol/water (3/2/1 ml) to yield 20 mg (37.7% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.55-8.51 (m, 3H), 8.23 (s, 1H), 8.12-8.09 (dd, 1H), 7.97 (s, 1H), 7.73 (s, 1H), 7.40-7.30 (m, 1H), 7.15-7.10 (m, 2H), 7.06-7.00 (m, 2H), 5.45 (s, 2H), 3.79-3.76 (t, 2H), 3.60-2.90 (m, 8H). MS: m/z=512.15 (M+1), HPLC: 95.27% in method A.

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