HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 90031578, compound → HCID 118524106, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 90031578 | HCID 90031578 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 118524106 | HCID 118524106 | 161.1% |
Reaction Steps
Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-chlorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperazine-1-carboxylate (185 mg, 0.25 mmol) was deprotected in HCl in ether (10 ml) to afford 133 mg (78.8% yield) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-17aa8db992b24caeb38865d229917af9 |
| Source note | uspto-grants-2016_05 |