Lithium Hydroxide → HCID 90030749, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(5-(3-(1-(3-chlorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperazin-1-yl) propan-2-ol (124 mg, 0.181 mmol) was hydrolyzed with lithium hydroxide (38 mg, 0.908 mmol) in THF/methanol/water (2/2/1 mL) to yield 30 mg (26.0% yield). 1H NMR (CD3OD, 300 MHz): δ 8.54-8.53 (d, 1H), 8.45-8.41 (d, 1H), 8.41-8.40 (d, 1H), 8.21 (s, 1H), 8.07-8.03 (dd, 1H), 7.957-7.955 (d, 1H), 7.68 (s, 1H), 7.34-7.30 (m, 3H), 7.24-7.21 (dt, 1H), 7.11-7.08 (d, 1H), 5.42 (s, 2H), 4.30-4.20 (m, 1H), 3.26-3.08 (m, 2H), 1.27-1.25 (d, 3H). MS: m/z=528.4 (M+1), HPLC: 97.22% in method A.

Provenance & Evidence