Lithium Hydroxide → HCID 90031360, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 1-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperidin-4-ol (160 mg, 0.25 mmol) was hydrolyzed with lithium hydroxide (33 mg, 0.77 mmol) in THF/methanol/water (3/3/1 mL) to yield 38 mg (25.4%) of desired product. 1H NMR (CD3OD, 300 MHz): δ 8.49-8.41 (m, 3H), 8.21 (s, 2H), 7.98 (s, 1H), 7.70 (s, 1H), 7.55-7.51 (s, 1H), 7.42-7.33 (m, 1H), 7.11-6.97 (m, 3H), 5.43 (s, 2H), 4.06-3.98 (m, 3H), 3.65-3.57 (m, 2H), 2.09-2.03 (m, 2H), 1.80-1.65 (m, 2H). MS: m/z=469.2 (M+1), HPLC: 93.72% in method A.

Provenance & Evidence