Lithium Hydroxide → HCID 118524089, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperidine-1-carboxylate (step ii of example 102A) (126 mg, 0.178 mmol) was hydrolyzed by lithium hydroxide (75 mg, 1.78 mmol) in THF/methanol/water (20/10/5 ml) to yield 96 mg (98% yield) of the titled compound. MS: m/z=553.2 (M+1).

Provenance & Evidence