Lithium Hydroxide → HCID 90064846, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 2-cyclopropyl-1-(4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperazin-1-yl) ethanone (80 mg, 0.116 mmol) was hydrolyzed with lithium hydroxide (25 mg, 0.58 mmol) in THF/methanol/water (3/2/1 mL) to yield 4 mg (6.4% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.52-8.45 (m, 3H), 8.33-8.32 (d, 1H), 8.225-8.222 (d, 1H), 7.993-7.990 (d, 1H), 7.73 (s, 1H), 7.50-7.46 (d, 1H), 7.38-7.33 (m, 1H), 7.12-7.09 (d, 1H), 7.04-6.89 (m, 3H), 6.50-6.43 (dt, 1H), 5.44 (s, 2H), 3.93-3.85 (m, 8H), 2.35-2.25 (m, 2H), 1.13-1.08 (t, 3H). MS: m/z=536.4 (M+1), HPLC: 97.55% in method B.

Provenance & Evidence