Diisopropylethylamine → HCID 90031364, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(6-(piperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride (186 mg. 0.277 mmol) was alkylated using (S)-2-methyloxirane (32 mg, 0.554 mmol), DIPEA (72 mg, 0.554 mmol) and ethanol (4 mL) to get 157 mg (82% yield) of the titled compound. MS: m/z=694.2 (M+1).

Provenance & Evidence