Hydrochloric Acid → HCID 118524025, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazin-2-yl)piperazine-1-carboxylate (400 mg, 0.56 mmol) was deprotected in HCl in ether (10 ml) to afford crude compound. Using similar reaction conditions as described in Step-i of example-82A, above crude was alkylated using (S)-2-methyloxirane (163 mg, 2.8 mmol), DIPEA (217 mg, 1.68 mmol) and ethanol (10 mL) to get 240 mg (63.7% yield) of the titled compound. MS: m/z=667.1 (M+1).

Provenance & Evidence