反应详情

Using similar reaction conditions as described in step-i of example-1, tert-butyl 4-(2-fluoro-4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (intermediate 66Q) (170 mg, 0.253 mmol) was coupled with 1-phenethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 59) (151 mg, 0.506 mmol) using Pd(dppf)Cl2 (10 mg, 0.012 mol) and sodium carbonate (161 mg, 0.759 mmol) in toluene/ethanol/water (20/10/5 ml) to afford 171 mg (94% yield) of the titled. MS: m/z=718.3 (M+1).

1. customreaction conditions
2. customto afford 171 mg (94% yield) of the