反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(2-fluoro-4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (140 mg, 0.194 mmol) was hydrolyzed by sodium hydroxide (78 mg, 1.947 mmol) in THF/methanol/water (12/4/3 mL) to yield 83 mg (75% yield) of the titled compound. MS: m/z=566.3 (M+1).

1. customreaction conditions