反应详情

温度

80 °C

The method followed that described in Example 2, but using 3-acetoxy-17-(3-pyridyl)estra-1,3,5[10],16-tetraene (2.368, 6.3 mmol), methanol (40 ml), aqueous sodium hydroxide (10% w/v, 5 ml), and the mixture was heated at 80° C. for 10 min. Chromatography, on elution with toluene-methanol (8:1 ), afforded the title compound (1.40 g, 67%) which crystallised from toluene, m.p. 256°-258° C.: 1H-NMR(DMSO) inter alia δ 1.01(3H,s, 18-CH3),

1. washChromatography, on elution with toluene-methanol (8:1 )