反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(2-fluoro-4-(3-(1-phenethyl-1H-pyrazol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (102 mg, 0.141 mmol) was hydrolyzed by sodium hydroxide (57 mg, 1.418 mmol) in THF/methanol/water (12/4/4 ml) to yield 67 mg (84% yield) of the titled compound. MS: m/z=566.5 (M+1).

1. customreaction conditions