HCID 118524103, compound → HCID 90031650, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-methoxypyridin-2-yl)piperazine-1-carboxylate (91 mg, 0.156 mmol) was deprotected in methanol/HCl in dioxane (5/5 ml) to afford 52 mg (56% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.727-8.722 (d, 1H), 8.626-8.622 (d, 1H), 8.29 (s, 1H), 8.19-8.18 (d, 1H), 8.00 (s, 1H), 7.81 (s, 1H), 7.75-7.74 (d, 1H), 7.37-7.35 (q, 1H), 7.12-7.10 (d, 1H), 7.02-6.99 (m, 2H), 5.44 (s, 2H), 4.03 (s, 3H), 3.78-3.74 (t, 4H), 3.39-3.32 (m, 4H). MS: m/z=484.3 (M+1), HPLC: 97.58% in method A.

Provenance & Evidence