HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 118524051, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperidin-4-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride | HCID 118524085 | — |
| Reactant | HCID 118524115 | HCID 118524115 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 118524051 | HCID 118524051 | 89% |
Reaction Steps
Using similar reaction conditions as described in step-iii of example-133, 5-(5-fluoro-6-(piperazin-1-yl)pyridin-3-yl)-3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (170 mg, 0.272 mmol) was methylated using paraformaldehyde (24 mg, 0.816 mmol), Na(OAc)3BH (172 mg, 0.816 mmol) and 3 drops of acetic acid in dichloroethane (10 mL) to afford 154 mg (89% yield) of the titled compound. MS: m/z=640.6 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-74b9f4c72fb94f1e8537e8e061afd040 |
| Source note | uspto-grants-2016_05 |