Diisopropylethylamine → HCID 118523945, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-i of example-82A, 5-(5-fluoro-6-(piperazin-1-yl)pyridin-3-yl)-3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (product of step 1 of example 179) (127 mg, 0.203 mmol) was alkylated using (S)-2-methyloxirane (23 mg, 0.406 mmol), DIPEA (105 mg, 0.812 mmol) and ethanol (5 mL) to get 135 mg (97.8% yield) of the titled compound. MS: m/z=684.7 (M+1).

Provenance & Evidence