HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 131735687, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperidin-4-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride | HCID 118524085 | — |
| Reactant | HCID 131735686 | HCID 131735686 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | HCID 131735687 | HCID 131735687 | 91.9% |
Reaction Steps
Using similar reaction conditions as described in step-iii of example-1, tert-butyl (3-fluoro-5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)carbamate (110 mg, 0.16 mmol) was hydrolyzed by lithium hydroxide (33 mg, 0.8 mmol) in THF/methanol/water (5/5/2 mL) to yield 78 mg (91.5% yield) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-8d2f4c9c85304713a2b8227923fa4465 |
| Source note | uspto-grants-2016_05 |