Lithium Hydroxide → HCID 72944957, compound

Participants

Reaction Steps

Using the same reaction conditions as described in step-iii of example-1, 2-(4-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl) piperazin-1-yl)ethanol (58 mg, 0.085 mmol) was hydrolyzed by lithium hydroxide (36 mg, 0.85 mmol), THF/Methanol/water (12/6/3 ml) to yield 7 mg (16%) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.46-8.45 (d, 1H), 7.87-7.86 (d, 1H), 7.39-7.31 (m, 3H), 7.16 (s, 1H), 7.10-7.08 (m, 1H), 7.04-6.97 (m, 3H), 6.87-6.84 (m, 1H), 3.75-3.74 (t, 2H), 2.82 (b, 4H), 2.53 (m, 2H), 2.21 (s, 3H), 2.17 (s, 3H). MS: m/z=525.0 (M+1), HPLC: 91.007% in method A.

Provenance & Evidence