Methyl iodide → HCID 57883721, compound

HRID 531937Notes

Reaction equation

HRID 531937 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:13][C:14]([N:16]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[S:9][C:10]=1[S:11][CH3:12])=[O:5])C.C(OC(C1N=C(NC(N(C2CCCCC2)C2CCCCC2)=O)SC=1SC#N)=O)C.CI>>[CH:23]1([N:16]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[C:14](=[O:15])[NH:13][C:8]2[S:9][C:10]([S:11][CH3:12])=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 86611185HCID 86611185, compoundHCID 86611186HCID 86611186, compound

Product 1

HCID 57883721HCID 57883721, compound

Procedure

2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester was pre-pared as described in general procedure (H) using 2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester and methyl iodide. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-161fccc84bf84ac0b13d59920d434a0e
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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