HCID 66872294, compound → HCID 178501021, compound

HRID 531959Notes

Reaction equation

HRID 531959 reaction equation
[CH:1]1([N:8]([C@H:19]2[CH2:24][CH2:23][C@H:22]([CH3:25])[CH2:21][CH2:20]2)[C:9]([NH:11][C:12]2[S:13][C:14]([CH:17]=O)=[CH:15][N:16]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[CH3:27][O:28][C:29]([CH2:31][CH2:32][S:33]([N:36]1[CH2:41][CH2:40][NH2+:39][CH2:38][CH2:37]1)(=[O:35])=[O:34])=[O:30]>>[CH3:27][O:28][C:29](=[O:30])[CH2:31][CH2:32][S:33]([N:36]1[CH2:37][CH2:38][N:39]([CH2:17][C:14]2[S:13][C:12]([NH:11][C:9]([N:8]([CH:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C@H:19]3[CH2:20][CH2:21][C@H:22]([CH3:25])[CH2:23][CH2:24]3)=[O:10])=[N:16][CH:15]=2)[CH2:40][CH2:41]1)(=[O:34])=[O:35]

Participants

3

Reactant 2

HCID 66872294HCID 66872294, compoundHCID 178461375HCID 178461375, compound

Product 1

HCID 178501021HCID 178501021, compound

Procedure

Prepared in 65% (380 mg) yield as described in general procedure (B) from trans-1-cycloheptyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea (364 mg, 1.0 mmol) and 4-(2-methoxycarbonyl-ethanesulfonyl)-piperazin-1-ium chloride (273 mg, 1 mmol).

Workup

  1. customPrepared in 65% (380 mg)
  2. customyield

Sources & evidence

ORD record
ord-3bc5b07f3235400ba1b4566e0f9bfc29
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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