HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 531991Erstellt: 26. Oktober 2026
1,1'-Carbonyldiimidazole → 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/531991
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Edukt | 2-Amino-1,3-thiazole-5-carbaldehyde | HCID 2737798 | — |
| Edukt | 4-(4-Methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 43652146 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57883803 | 357,1% |
Reaktionsschritte
Prepared in a manner similar to general procedure (C) using 5-formyl-2-aminothiazole (1.88 g, 14.6 mmol), 4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.32 mg, 14.6 mmol), catalytic DMAP, CDI (2.60 g, 1.1 mmol) and THF with heating to 65° C. afforded 1.77 g (27%) of the desired product after purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | USRE045183E1 |
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| Quelldatensatz | uspto-grants-2014_10 |
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| ORD ID | ord-9c3fc7b8404b4913994c2f23dfc02c57 |
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| Quellennotiz | uspto-grants-2014_10 |
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