Lithium borohydride → HCID 57883708, compound

HRID 532000Notes

Reaction equation

HRID 532000 reaction equation
[CH:1]1([N:7]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH:16]=[O:17])=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Li+]>CO>[CH:18]1([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH2:16][OH:17])=[CH:14][N:15]=2)=[O:9])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 4148881Lithium borohydrideHCID 578834711,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

Product 1

HCID 57883708HCID 57883708, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (50 mg, 0.15 mmol) and lithium borohydride (95 μL, 2M in THF) in MeOH (1 mL). Purification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2) afforded 49 mg (97%) of the desired compound.

Workup

  1. customPrepared
  2. customPurification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2)

Sources & evidence

ORD record
ord-7e60a35bb7a94479a42ae24f39ba8dad
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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