Glycine methyl ester → {[2-(3,3-Dicyclohexyl-ureido)-thiazole-4-carbonyl]-amino}-acetic acid methyl ester

HRID 532001Notes

Reaction equation

HRID 532001 reaction equation
[CH:1]1([N:7]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:8](=[O:18])[NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15](O)=[O:16])[N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][O:26][C:27](=[O:30])[CH2:28][NH2:29]>>[CH3:25][O:26][C:27](=[O:30])[CH2:28][NH:29][C:15]([C:13]1[N:14]=[C:10]([NH:9][C:8]([N:7]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:18])[S:11][CH:12]=1)=[O:16]

Participants

3

Reactant 2

HCID 69221Glycine methyl esterHCID 578836042-(3,3-Dicyclohexylureido)-thiazole-4-carboxylic acid

Product 1

HCID 57883663{[2-(3,3-Dicyclohexyl-ureido)-thiazole-4-carbonyl]-amino}-acetic acid methyl esterYield 30%

Procedure

Prepared in 30% yield (76 mg) as described in general procedure (K) from 2-(3,3-dicyclohexylureido)-thiazole-4-carboxylic acid (210 mg, 0.6 mmol) and glycine methyl ester (HCl salt, 75 mg, 0.6 mmol).

Workup

  1. customPrepared in 30% yield (76 mg)

Sources & evidence

ORD record
ord-be7059dc713b408d8f030f1484e366a5
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

Loading…