HCID 9118520, compound → HCID 57883578, compound

HRID 532010Notes

Reaction equation

HRID 532010 reaction equation
C([O:3][C:4](=[O:28])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:21]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(NC2CCCC2)CCCCCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:21]1([N:15]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:28])=[O:3])=[CH:8][N:9]=2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 9118520HCID 9118520, compoundHCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86633695HCID 86633695, compound

Product 1

HCID 57883578HCID 57883578, compound

Procedure

[2-(3-Cycloheptyl-3-cyclopentyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cycloheptyl-cyclopentylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-f33651542ac443e79744bb996ad38426
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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