HCID 9118520, compound → HCID 57883560, compound

HRID 532014Notes

Reaction equation

HRID 532014 reaction equation
C(OC(=O)[CH:5]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([CH:22]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])=[N:10][CH:9]=1)[CH3:6])C.C1(NC2CCCC2)CCCCCC1.NC1SC=NC=1.C([O:51][C:52](=[O:55])CS)C>>[CH:22]1([N:16]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:5][CH2:6][C:52]([OH:55])=[O:51])=[CH:9][N:10]=2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

4

Reactant 3

HCID 9118520HCID 9118520, compoundHCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86611212[2-(3-Cycloheptyl-3-cyclopentyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester

Product 1

HCID 57883560HCID 57883560, compound

Procedure

[2-(3-Cycloheptyl-3-cyclopentyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester pre-pared as described in general procedure (A) using cycloheptyl-cyclopentylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-321e26b7602e47398405104d506cb837
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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