Dichloromethane → HCID 57883840, compound

HRID 532019Notes

Reaction equation

HRID 532019 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[C:11]([NH:13][C:14]2[S:15][C:16](SC)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].O[O:28][S:29]([O-:31])=O.[K+].Cl[CH2:34]Cl>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([N:10]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:29]([CH3:34])(=[O:31])=[O:28])=[CH:17][N:18]=2)=[O:12])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 23707502Potassium hydroxy sulfiteHCID 57883753HCID 57883753, compound

Product 1

HCID 57883840HCID 57883840, compound

Procedure

Prepared by oxidising 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea (Example 339) using montmorillonite clay, oxone (2.5 equivalents) for 16 h at room temperature in dichloromethane. The title compound was purified by HPLC.

Workup

  1. customPrepared
  2. customfor 16 h
  3. customat room temperature
  4. customThe title compound was purified by HPLC

Sources & evidence

ORD record
ord-8ef920f77b804d798ef80e4d93cbe274
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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