HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloroethyl)pyrrolidine → 1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-[5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloroethyl)pyrrolidine | HCID 81669 | — |
| Reactant | Dithioerythritol | HCID 439352 | — |
| Reactant | 1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea | HCID 86611190 | — |
| Product | 1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-[5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-urea | HCID 57883587 | — |
Reaction Steps
Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and N-(2-chloroethyl)pyrrolidine. HPLC-MS: m/z 480 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045183E1 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a945f3188ecb4ac2aa1a39d3b9c9fab4 |
| Source note | uspto-grants-2014_10 |