1-(2-Chloroethyl)piperidine → HCID 178473846, compound

HRID 532028Notes

Reaction equation

HRID 532028 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([C@H:22]2[CH2:27][CH2:26][C@H:25]([CH3:28])[CH2:24][CH2:23]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19]C#N)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].SC[C@@H]([C@@H](CS)O)O.Cl[CH2:38][CH2:39][N:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([N:10]([C@H:22]2[CH2:23][CH2:24][C@H:25]([CH3:28])[CH2:26][CH2:27]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:38][CH2:39][N:40]3[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]3)=[CH:17][N:18]=2)=[O:12])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 748271-(2-Chloroethyl)piperidineHCID 439352DithioerythritolHCID 178473855HCID 178473855, compound

Product 1

HCID 178473846HCID 178473846, compound

Procedure

Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-(trans-4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and N-(2-chloroethyl)piperidine

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6940259e5ae74509a93fbb42032e4ed0
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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