HCID 28423727, compound → HCID 57883674, compound

HRID 532052Notes

Reaction equation

HRID 532052 reaction equation
C(OC(=O)[CH:5]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([CH:23]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])=[N:10][CH:9]=1)C)C.C1(NC2CCCCC2)CCCCCC1.NC1SC=NC=1.C([O:53][C:54](=[O:57])[CH2:55]S)C>>[CH:23]1([N:16]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:5][CH2:55][C:54]([OH:53])=[O:57])=[CH:9][N:10]=2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

4

Reactant 3

HCID 28423727HCID 28423727, compoundHCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86611227[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester

Product 1

HCID 57883674HCID 57883674, compound

Procedure

[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester pre-pared as described in general procedure (A) using cycloheptyl-cyclohexylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-d8d44b52843e4c3db6e159e8c1e5ab13
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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