HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 14871689, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 3-Methoxyacetophenone | HCID 11460 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Product | HCID 14871689 | HCID 14871689 | — |
Reaction Steps
Patent publication WO2004/037771 describes reductive amination of 3-methoxy acetophenone in presence of dimethylamine, titanium isopropoxide and sodium borohydride to obtain [1-(3-methoxyphenyl)ethyl]dimethylamine, which is further demethylated using hydrobromic acid to obtain 3-(1-dimethylamino)phenol. This is further resolved using (S)-(+)camphor-10-sulfonic acid and reacted with carbamoyl chloride to obtain rivastigmine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08852900B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-044ff2aebf0c4abebd6384fc038824ca |
| Source note | uspto-grants-2014_10 |