Water → HCID 57524486, compound

Participants

Reaction Steps

To a stirred solution of (S)—N-{2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide (0.55 mmol) in anhydrous CH2Cl2 at room temperature, is added Ala (1.10 mmol). After stirring for 1 hour, water is added. The product is extracted into CH2Cl2 and is dried over Na2SO4. The solvent is removed to give crude (S)—N—{2-[1-(3-hydroxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide. The product is purified by chromatography or recrystallization.

Provenance & Evidence