Aluminum(III) Chloride → HCID 57524485, compound

Participants

Reaction Steps

To a stirred solution of (S)—N-{2-[1-(3-ethoxy-4-hydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide (0.55 mmol) in anhydrous CH2C2 at room temperature, is added AlCl3 (1.10 mmol). After stirring for 1 hour, water is added. The product is extracted with CH2Cl2, and the organic extract is dried over MgSO4. The solvent is removed to give crude (S)—N-{2-[1-(3,4-dihydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide. The product is purified by column chromatography or recrystallization.

Provenance & Evidence